Health Benefits of Melatonin


Melatonin is a powerful antioxidant neurotransmitter produced not only by the pineal gland in the brain but it is also made in the skin and possibly other tissues. Levels of this vital substance tend to decline as we age (in both the skin and in the brain).

Melatonin is widely known as a natural sleep-promoting compound, but research has shown that melatonin offers other remarkable health promoting benefits.

Melatonin helps protect against cancer
The confirmed mechanisms of its cancer inhibitory abilities include:

Its ability to regulate estrogen receptor expression and activation. Estrogens promote the growth of many types of tumors, like breast ovarian, uterine and even prostate cancers.

  • Its ability to modulate the production of estrogen.
  • Its ability to activate cell mechanisms that promote cancer cell death (apoptosis).
  • Its ability to suppress the telomerase activity that makes cancer cells immortal.
  • Its ability to help prevent the spread of cancers throughout the body (metastasis inhibition).
  • Its ability to suppress the growth of blood vessels that feed cancer tumors (anti-angiogenesis).
  • Its ability to stimulate cell differentiation, which makes cancer cells less “cancerous”.
  • Its ability to stimulate immune system mechanisms that suppress cancerous tumors.
  • And by several other mechanisms including its antioxidant effects.

Basic Mechanisms Involved in the Anti-Cancer Effects of Melatonin; Current Medicinal Chemistry, 2010, 17, 4462-4481

Melatonin helps protect the skin and supports skin health
Melatonin is naturally produced in the skin and offers many skin protective effects. These include inhibiting the formation of wrinkles and age spots, enhancing the elasticity of skin and ameliorating the effects of sunburn by suppressing ultraviolet-induced damage to skin cells. Melatonin “exhibits strong antioxidant activity in cells exposed to ultraviolet radiation.”
On the Role of Melatonin in Skin Physiology and Pathology; Endocrine. 2005 July; 27(2): 137–148.

Melatonin offers many other health-promoting benefits
Research also confirms the beneficial effects of melatonin as supportive (adjuvant) therapy for a wide variety of conditions including:

  • Macular degeneration, a common cause of vision loss
  • Glaucoma, another common cause of vision loss
  • Protection of the stomach lining (gastric mucosa)
  • Irritable bowel syndrome
  • Arterial hypertension (high blood pressure)
  • Helping to lessen the side effects of chemotherapy and radiation in cancer patients
  • Helping to lessen the side effects of hemodialysis in patients with kidney disease
  • Relief of sleep disorders, especially those that have to do with the disruption of the normal sleep-wake cycle (trouble falling asleep, jet-lag, shift changes and age-related sleep disorders including neurodegenerative conditions like Alzheimer’s disease).
  • Its additive benefits when used in anesthetic procedures.
  • Its ability to enhance the production of glutathione via a variety of mechanisms including enhancing the expression and activity of a variety of glutathione related enzymes. Glutathione is a vitally important antioxidant and detoxifier which supports the health of cells and tissues throughout the body.

Clinical Uses of Melatonin: Evaluation of Human Trials; Current Medicinal Chemistry, 2010, 17, 2070-2095.

The Glutathione System and its Regulation by Neurohormone Melatonin in the Central Nervous System; Central Nervous System Agents in Medicinal Chemistry, 2010, 10, 287-297 287

This product is not intended to diagnose, cure or treat cancer.
Melatonin has no adverse side effects or long-term risks.

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